منابع مشابه
Chromosomal Aneuploidies and Early Embryonic Developmental Arrest
Background Selecting the best embryo for transfer, with the highest chance of achieving a vital pregnancy, is a major goal in current in vitro fertilization (IVF) technology. The high rate of embryonic developmental arrest during IVF treatment is one of the limitations in achieving this goal. Chromosomal abnormalities are possibly linked with chromosomal arrest and selection against abnormal fe...
متن کاملGenomic Instability during Early Differentiation of Embryonic Stem Cells
Objective: Understanding how genomic instability could be involved in the regulation and establishment of cell lineage commitment during embryonic stem cell differentiation would provide crucial knowledge of stem cell biology. The aim of this study was to determine novel molecular biomarkers located near embryonic developmental genes responsible for embryonic stem cell signals that govern in vi...
متن کاملSubstrate stiffness affects early differentiation events in embryonic stem cells.
Embryonic stem cells (ESC) are both a potential source of cells for tissue replacement therapies and an accessible tool to model early embryonic development. Chemical factors such as soluble growth factors and insoluble components of the extracellular matrix are known to affect the differentiation of murine ESCs. However, there is also evidence to suggest that undifferentiated cells can both se...
متن کاملRole of the Transcriptional Corepressor Bcor in Embryonic Stem Cell Differentiation and Early Embryonic Development
Bcor (BCL6 corepressor) is a widely expressed gene that is mutated in patients with X-linked Oculofaciocardiodental (OFCD) syndrome. BCOR regulates gene expression in association with a complex of proteins capable of epigenetic modification of chromatin. These include Polycomb group (PcG) proteins, Skp-Cullin-F-box (SCF) ubiquitin ligase components and a Jumonji C (Jmjc) domain containing histo...
متن کاملReview Paper: Embryonic Stem Cell and Osteogenic Differentiation
Bone tissue engineering has been one of the most promising areas of research, providing a potential clinical application to cure bone defects. Recently, various stem cells, including embryonic stem cells (ESCs), bone marrow-derived mesenchymal stem cells (BM-MSCs), umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs), adipose tissue-derived stem cells (ADSCs), muscle-derived stem cell...
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ژورنال
عنوان ژورنال: Nature
سال: 1924
ISSN: 0028-0836,1476-4687
DOI: 10.1038/113276a0